Letteratura scientifica

sulla Disfunzione Sessuale Post SSRI/SNRI (PSSD)

​Ultimo aggiornamento: Marzo 2023

Bibliografia sulla Disfunzione Sessuale Post-SSRI

De Luca R, Bonanno M, Manuli A, Calabrò RS. Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study. Medicines (Basel). 2022 Sep 1;9(9). pii: 45. doi: 10.3390/medicines9090045. [PubMed] [PMC]

Reisman, Y., Jannini, T. B., & Jannini, E. A. (2022). Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical Experience with a Multimodal Approach. Journal of Men’s Health, 18(8), 165. [CrossRef] [PDF researchgate.net]

Reisman, Y., Pfaus, J. G., & Lowenstein, L. (2022). Post-SSRI Sexual Dysfunction (PSSD). In Textbook of Rare Sexual Medicine Conditions (pp. 51-63). Springer, Cham. [CrossRef] [SpringerLink]

Schifano, N., Capogrosso, P., Fallara, G., Pozzi, E., Belladelli, F., Candela, L., … & Salonia, A. (2022). MP21-09 DRUG-RELATED SEXUAL DYSFUNCTION ISSUES AMONG PATIENTS UNDER TREATMENT OR PREVIOUSLY EXPOSED TO SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)—A MANAGEMENT CHALLENGE?. The Journal of Urology, 207(Supplement 5), e330. [CrossRef]

Hutters, C. L., & Giraldi, A. (2022). Sexual side effects from treatment with SSRI. Ugeskrift for Laeger, 184(14). [PubMed]

Achour V, Masson M, Lancon C, Boyer L, Fond G. Screening and treatment of Post-Selective Serotonin Reuptake Inhibitors sexual dysfunctions. Encephale. 2022 Dec;48(6):599-600. doi: 10.1016/j.encep.2022.07.001. Epub 2022 Aug 12. [PubMed]

Chinchilla Alfaro K, van Hunsel F, Ekhart C. Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands. Expert Opin Drug Saf. 2022 Apr;21(4):553-561. doi: 10.1080/14740338.2022.2007883. Epub 2021 Nov 27. Review. [PubMed]

Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D’Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJG, Irwig MS, Jannini EA, Janssen PKC, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DEJ, et al. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. Int J Risk Saf Med. 2022;33(1):65-76. doi: 10.3233/JRS-210023. [PubMed] [PMC] 

Peleg LC, Rabinovitch D, Lavie Y, Rabbie DM, Horowitz I, Fruchter E, Gruenwald I. Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors. Sex Med Rev. 2022 Jan;10(1):91-98. doi: 10.1016/j.sxmr.2021.07.001. Epub 2021 Oct 7. Review. [PubMed]

Studt A, Gannon M, Orzel J, Vaughan A, Pearlman AM. Characterizing post-SSRI sexual dysfunction and its impact on quality of life through an international online survey. Int J Risk Saf Med. 2021;32(4):321-329. doi: 10.3233/JRS-210039. [PubMed]

Giatti S, Diviccaro S, Cioffi L, Falvo E, Caruso D, Melcangi RC. Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis. Psychoneuroendocrinology. 2021 Oct;132:105364. doi: 10.1016/j.psyneuen.2021.105364. Epub 2021 Jul 21. [PubMed]

Patacchini A, Cosci F. Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey. Int J Risk Saf Med. 2021;32(3):229-242. doi: 10.3233/JRS-200074. [PubMed]

Rothmore J. Antidepressant-induced sexual dysfunction. Med J Aust. 2020 Apr;212(7):329-334. doi: 10.5694/mja2.50522. Epub 2020 Mar 15. Review. [PubMed]

Waraich A, Clemons C, Ramirez R, Yih J, Goldstein S, Goldstein I. Post-SSRI sexual dysfunction (PSSD): Ten year retrospective chart review. J Urol. 2020;203:e1179. [CrossRef]

Healy D, LaPalme J, Levin M. Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism? Bioelectricity. 2020 Mar 1;2(1):7-13. doi: 10.1089/bioe.2019.0010. Epub 2020 Mar 18. [PubMed] [PMC]

Reisman Y. Post-SSRI sexual dysfunction. BMJ. 2020 Feb 27;368:m754. doi: 10.1136/bmj.m754. [PubMed]

Healy D. Antidepressants and sexual dysfunction: a history. J R Soc Med. 2020 Apr;113(4):133-135. doi: 10.1177/0141076819899299. Epub 2020 Jan 23. [PubMed] [PMC]

Patacchini A, Cosci F. A Paradigmatic Case of Postselective Serotonin Reuptake Inhibitors Sexual Dysfunction or Withdrawal After Discontinuation of Selective Serotonin Reuptake Inhibitors? J Clin Psychopharmacol. 2020 Jan/Feb;40(1):93-95. doi: 10.1097/JCP.0000000000001154. [PubMed]

Reisman, Y. Are There Any Sex/Gender Differences in Post-Selective Serotonin Reuptake Inhibitors (SSRI) Sexual Dysfunction (PSDD)?. Curr Sex Health Rep 11, 237–242 (2019). [CrossRef] [SpringerLink]

Healy D, Mangin D. Clinical judgments, not algorithms, are key to patient safety-an essay by David Healy and Dee Mangin. BMJ. 2019 Oct 2;367:l5777. doi: 10.1136/bmj.l5777. [PubMed]

Healy D. Post-SSRI sexual dysfunction & other enduring sexual dysfunctions. Epidemiol Psychiatr Sci. 2019 Sep 23;29:e55. doi: 10.1017/S2045796019000519. [PubMed] [PMC]

Moncrieff J. Persistent adverse effects of antidepressants. Epidemiol Psychiatr Sci. 2019 Sep 23;29:e56. doi: 10.1017/S2045796019000520. [PubMed] [PMC]

Healy D, Le Noury J, Mangin D. Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals. Int J Risk Saf Med. 2019;30(3):167-178. doi: 10.3233/JRS-191005. [PubMed]

Calabrò RS, De Luca R, Manuli A, Portaro S, Naro A, Quattrini F. Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study. J Sex Marital Ther. 2019;45(6):562-565. doi: 10.1080/0092623X.2018.1556755. Epub 2019 Feb 13. [PubMed]

Kanherkar RR, Getachew B, Ben-Sheetrit J, Varma S, Heinbockel T, Tizabi Y, Csoka AB. The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells. Int J Genomics. 2018 Jul 25;2018:8929057. doi: 10.1155/2018/8929057. eCollection 2018. [PubMed] [PMC]

Healy D. Citizen petition: Sexual side effects of SSRIs and SNRIs. Int J Risk Saf Med. 2018;29(3-4):135-147. doi: 10.3233/JRS-180745. [PubMed] [PMC]

Healy D, Le Noury J, Mangin D. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. Int J Risk Saf Med. 2018;29(3-4):125-134. doi: 10.3233/JRS-180744. [PubMed] [PMC]

Giatti S, Diviccaro S, Panzica G, Melcangi RC. Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin? Endocrine. 2018 Aug;61(2):180-193. doi: 10.1007/s12020-018-1593-5. Epub 2018 Apr 19. Review. [PubMed]

Coskuner ER, Culha MG, Ozkan B, Kaleagasi EO. Post-SSRI Sexual Dysfunction: Preclinical to Clinical. Is It Fact or Fiction? Sex Med Rev. 2018 Apr;6(2):217-223. doi: 10.1016/j.sxmr.2017.11.004. Epub 2018 Feb 17. Review. [PubMed]

Bala A, Nguyen HMT, Hellstrom WJG. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev. 2018 Jan;6(1):29-34. doi: 10.1016/j.sxmr.2017.07.002. Epub 2017 Aug 1. Review. [PubMed] 

Reisman Y. Sexual Consequences of Post-SSRI Syndrome. Sex Med Rev. 2017 Oct;5(4):429-433. doi: 10.1016/j.sxmr.2017.05.002. Epub 2017 Jun 20. Review. [PubMed]

Rodriguez, Omar Walid & Gómez-Moreno, Enrique & Fernández, Jennifer & García, Carmen & Fernández, María. (2017). Disfunción sexual persistente tras el tratamiento con inhibidores selectivos de la recaptación de serotonina: a propósito de un caso tras la retirada de paroxetina. Psiquiatría Biológica. 24. 10.1016/j.psiq.2017.05.004. [ScienceDirect]

Simonsen AL, Danborg PB, Gøtzsche PC. Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies. Int J Risk Saf Med. 2016 Mar 16;28(1):1-12. doi: 10.3233/JRS-160668. Review. [PubMed]

Waldinger MD. Psychiatric disorders and sexual dysfunction. Handb Clin Neurol. 2015;130:469-89. doi: 10.1016/B978-0-444-63247-0.00027-4. Review. [PubMed]

Ben-Sheetrit J, Aizenberg D, Csoka AB, Weizman A, Hermesh H. Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship. J Clin Psychopharmacol. 2015 Jun;35(3):273-8. doi: 10.1097/JCP.0000000000000300. [PubMed]

Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J. Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels. Eur J Pharmacol. 2015 Apr 15;753:263-8. doi: 10.1016/j.ejphar.2014.11.031. Epub 2014 Dec 4. [PubMed]

Hogan C, Le Noury J, Healy D, Mangin D. One hundred and twenty cases of enduring sexual dysfunction following treatment. Int J Risk Saf Med. 2014;26(2):109-16. doi: 10.3233/JRS-140617. [PubMed]

Ekhart GC, van Puijenbroek EP. [Does sexual dysfunction persist upon discontinuation of selective serotonin reuptake inhibitors?]. Tijdschr Psychiatr. 2014;56(5):336-40. Dutch. [PubMed]

Stinson, Rebecca Diane. “The impact of persistent sexual side effects of selective serotonin reuptake inhibitors after discontinuing treatment: a qualitative study.” PhD (Doctor of Philosophy) thesis, University of Iowa, 2013. http://ir.uiowa.edu/etd/5061. [PDF]

Bahrick, A.S., Harris, M.M. Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap. J Contemp Psychother 39, 135–143 (2009). [CrossRef] [SpringerLink]

Farnsworth KD, Dinsmore WW. Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors. Int J STD AIDS. 2009 Jan;20(1):68-9. doi: 10.1258/ijsa.2008.008402. [PubMed]

Bahrick, Audrey. (2008). Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence. The Open Psychology Journal. 1. 42-50. doi: 10.2174/1874350100801010042. [ResearchGate]

Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. J Sex Marital Ther. 2008;34(2):150-9. doi: 10.1080/00926230701636205. [PubMed]

Csoka AB, Bahrick A, Mehtonen OP. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med. 2008 Jan;5(1):227-33. doi: 10.1111/j.1743-6109.2007.00630.x. Erratum in: J Sex Med. 2008 Dec;5(12):2977.. Csoka, A [corrected to Csoka, AB]. [PubMed]

Kauffman, Robert & Murdock, Amanda. (2007). Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone. The Open Women’ Health Journal. 1. doi: 10.2174/187429120701011021. [ResearchGate]

Bolton JM, Sareen J, Reiss JP. Genital anaesthesia persisting six years after sertraline discontinuation. J Sex Marital Ther. 2006 Jul-Sep;32(4):327-30. [PubMed]

Csoka AB, Shipko S. Persistent sexual side effects after SSRI discontinuation. Psychother Psychosom. 2006;75(3):187-8. [PubMed]

Bahrick, Audrey & Audrey. (2006). Post SSRI Sexual Dysfunction. ASAP Tablet. 7. 2-3, 10. [ResearchGate]


Bibliografia sull’ottundimento emozionale indotto da antidepressivi

  1. Langley, C., Armand, S., Luo, Q., Savulich, G., Segerberg, T., Søndergaard, A., Pedersen, E. B., Svart, N., Overgaard-Hansen, O., Johansen, A., Borgsted, C., Cardinal, R. N., Robbins, T. W., Stenbæk, D. S., Knudsen, G. M., & Sahakian, B. J. (2023). Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study. Neuropsychopharmacology, 48(4), 664–670. https://doi.org/10.1038/s41386-022-01523-x
  2. Puścian, A., Winiarski, M., Łęski, S., Charzewski, Ł., Nikolaev, T., Borowska, J., Dzik, J. M., Bijata, M., Lipp, H., Dziembowska, M., & Knapska, E. (2021). Chronic fluoxetine treatment impairs motivation and reward learning by affecting neuronal plasticity in the central amygdala. British Journal of Pharmacology, 178(3), 672–688. Portico. https://doi.org/10.1111/bph.15319
  3. Padala, P. R., Padala, K. P., Majagi, A. S., Garner, K. K., Dennis, R. A., & Sullivan, D. H. (2020). Selective serotonin reuptake inhibitors-associated apathy syndrome. Medicine, 99(33), e21497. https://doi.org/10.1097/md.0000000000021497
  4. Rütgen, M., Pletti, C., Tik, M., Kraus, C., Pfabigan, D. M., Sladky, R., Klöbl, M., Woletz, M., Vanicek, T., Windischberger, C., Lanzenberger, R., & Lamm, C. (2019). Antidepressant treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy. Translational Psychiatry, 9(1). https://doi.org/10.1038/s41398-019-0496-4
  5. Read, J., & Williams, J. (2018). Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects. Current Drug Safety, 13(3), 176–186. https://doi.org/10.2174/1574886313666180605095130
  6. Kajanoja, J., Scheinin, N. M., Karukivi, M., Karlsson, L., & Karlsson, H. (2018). Is antidepressant use associated with difficulty identifying feelings? A brief report. Experimental and Clinical Psychopharmacology, 26(1), 2–5. https://doi.org/10.1037/pha0000165
  7. Goodwin, G. M., Price, J., De Bodinat, C., & Laredo, J. (2017). Emotional blunting with antidepressant treatments: A survey among depressed patients. Journal of Affective Disorders, 221, 31–35. https://doi.org/10.1016/j.jad.2017.05.048
  8. Marazziti, D., Akiskal, H. S., Udo, M., Picchetti, M., Baroni, S., Massimetti, G., Albanese, F., & Dell׳Osso, L. (2014). Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients. Journal of Affective Disorders, 166, 151–155. https://doi.org/10.1016/j.jad.2014.04.043
  9. Chen, W.-H., Chu, M.-Y., Chu, Y.-H., Lin, Y.-C., & Chen, K.-Y. (2017). Current Evidence of the Monoaminergic Regulation of Romantic Love and Relationship. Advances in Sexual Medicine, 07(03), 139–152. https://doi.org/10.4236/asm.2017.73011
  10. Read, J., Cartwright, C., & Gibson, K. (2014). Adverse emotional and interpersonal effects reported by 1829 New Zealanders while taking antidepressants. Psychiatry Research, 216(1), 67–73. https://doi.org/10.1016/j.psychres.2014.01.042
  11. Holguín-Lew, J. C., & Bell, V. (2013). “When I Want to Cry I Can’t”: Inability to Cry Following SSRI Treatment. Revista Colombiana de Psiquiatría, 42(4), 304–310. https://doi.org/10.1016/s0034-7450(13)70026-x
  12. Herzallah, M. M., Moustafa, A. A., Natsheh, J. Y., Abdellatif, S. M., Taha, M. B., Tayem, Y. I., Sehwail, M. A., Amleh, I., Petrides, G., Myers, C. E., & Gluck, M. A. (2013). Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants. Frontiers in Integrative Neuroscience, 7. https://doi.org/10.3389/fnint.2013.00067
  13. van der Veen, F. M., Jorritsma, J., Krijger, C., & Vingerhoets, A. J. (2011). Paroxetine reduces crying in young women watching emotional movies. Psychopharmacology, 220(2), 303–308. https://doi.org/10.1007/s00213-011-2477-z
  14. McCabe, C., Mishor, Z., Cowen, P. J., & Harmer, C. J. (2010). Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment. Biological Psychiatry, 67(5), 439–445. https://doi.org/10.1016/j.biopsych.2009.11.001
  15. Sansone, Randy A., and Lori A. Sansone. SSRI-induced indifferencePsychiatry (Edgmont) 7.10 (2010): 14. https://pubmed.ncbi.nlm.nih.gov/21103140/
  16. Price, J., Cole, V., & Goodwin, G. M. (2009). Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study. British Journal of Psychiatry, 195(3), 211–217. https://doi.org/10.1192/bjp.bp.108.051110
  17. Walsh, R., Victor, B., & Bitner, R. (2006). Emotional effects of sertraline: Novel findings revealed by meditation. American Journal of Orthopsychiatry, 76(1), 134–137. https://doi.org/10.1037/0002-9432.76.1.134
  18. Lee, S. I., & Keltner, N. L. (2005). Biological Perspectives. Antidepressant Apathy Syndrome. Perspectives In Psychiatric Care, 41(4), 188–192. https://doi.org/10.1111/j.1744-6163.2005.00033.x
  19. Opbroek, A., Delgado, P. L., Laukes, C., McGahuey, C., Katsanis, J., Moreno, F. A., & Manber, R. (2002). Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses? The International Journal of Neuropsychopharmacology, 5(02). https://doi.org/10.1017/s1461145702002870
  20. HOEHN-SARIC, R., LIPSEY, J. R., & McLEOD, D. R. (1990). Apathy and Indifference in Patients on Fluvoxamine. Journal of Clinical Psychopharmacology, 10(5), 343???345. https://doi.org/10.1097/00004714-199010000-00007
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